A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques

Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while obscuring unfavorable epitopes. Results from the RV144 trial highlighted the importance of vaccine-induced HIV-1 Env V1V2-directed ant...

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Veröffentlicht in:J Virol
Hauptverfasser: Jones, Andrew T., Chamcha, Venkateswarlu, Kesavardhana, Sannula, Shen, Xiaoying, Beaumont, David, Das, Raksha, Wyatt, Linda S., LaBranche, Celia C., Stanfield-Oakley, Sherry, Ferrari, Guido, Montefiori, David C., Moss, Bernard, Tomaras, Georgia D., Varadarajan, Raghavan, Amara, Rama Rao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809733/
https://ncbi.nlm.nih.gov/pubmed/29237847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01796-17
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