Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

Models for regulation of the eukaryotic heat shock response typically invoke a negative feedback loop consisting of the transcriptional activator Hsf1 and a molecular chaperone. Previously we identified Hsp70 as the chaperone responsible for Hsf1 repression and constructed a mathematical model that...

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Veröffentlicht in:eLife
Hauptverfasser: Krakowiak, Joanna, Zheng, Xu, Patel, Nikit, Feder, Zoë A, Anandhakumar, Jayamani, Valerius, Kendra, Gross, David S, Khalil, Ahmad S, Pincus, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809143/
https://ncbi.nlm.nih.gov/pubmed/29393852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31668
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