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Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity

Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a population. Heat shock factor 1 (Hsf1) regulates chapero...

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Podrobná bibliografie
Vydáno v:Cell Rep
Hlavní autoři: Zheng, Xu, Beyzavi, Ali, Krakowiak, Joanna, Patel, Nikit, Khalil, Ahmad S., Pincus, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893160/
https://ncbi.nlm.nih.gov/pubmed/29562166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.083
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