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Siderophore-fluoroquinolone conjugates containing potential reduction-triggered linkers for drug release: synthesis and antibacterial activity
Syntheses of two siderophore-fluoroquinolone conjugates with a potential reduction triggered linker for drug release are described. The “trimethyl lock” based linker incorporated in the conjugates was designed to be activated by taking advantage of the reductive pathway of bacterial iron metabolism....
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| Vydáno v: | Biometals |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808879/ https://ncbi.nlm.nih.gov/pubmed/25663417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-015-9830-3 |
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