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Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers

Two desferrioxamine B-ciprofloxacin conjugates with “trimethyl-lock” based linkers that are designed to release the antibiotic after esterase or phosphatase-mediated hydrolysis were synthesized. The potential esterase-sensitive conjugate 13 displayed moderate to good antibacterial activities against...

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Detalhes bibliográficos
Main Authors: Ji, Cheng, Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364023/
https://ncbi.nlm.nih.gov/pubmed/22608921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.034
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