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Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers
Two desferrioxamine B-ciprofloxacin conjugates with “trimethyl-lock” based linkers that are designed to release the antibiotic after esterase or phosphatase-mediated hydrolysis were synthesized. The potential esterase-sensitive conjugate 13 displayed moderate to good antibacterial activities against...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364023/ https://ncbi.nlm.nih.gov/pubmed/22608921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.034 |
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