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Iron Transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-catecholate Sidero-phore-Aminopenicillin Conjugates Reveals Selectively Potent Anti-Pseudomonal Activity

An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P....

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Detalhes bibliográficos
Main Authors: Ji, Cheng, Miller, Patricia A., Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380153/
https://ncbi.nlm.nih.gov/pubmed/22656303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303446w
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