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Siderophore-fluoroquinolone conjugates containing potential reduction-triggered linkers for drug release: synthesis and antibacterial activity

Syntheses of two siderophore-fluoroquinolone conjugates with a potential reduction triggered linker for drug release are described. The “trimethyl lock” based linker incorporated in the conjugates was designed to be activated by taking advantage of the reductive pathway of bacterial iron metabolism....

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Foilsithe in:Biometals
Main Authors: Ji, Cheng, Miller, Marvin J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808879/
https://ncbi.nlm.nih.gov/pubmed/25663417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-015-9830-3
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