β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells

Malignant glioblastoma multiforme is one of the most aggressive human cancers, with very low survival rates. Recent studies have reported that glioma stem-like cells transdifferentiate into endothelial cells, indicating a new mechanism for tumor angiogenesis and potentially providing new therapeutic...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Cui, Chunhong, Chen, Xiaoning, Liu, Ying, Cao, Benjin, Xing, Yang, Liu, Chanjuan, Yang, Fan, Li, Yinan, Yang, Tianxiao, Hua, Lingyang, Tian, Mi, Wei, Yuanyan, Gong, Ye, Jiang, Jianhai
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808780/
https://ncbi.nlm.nih.gov/pubmed/29269413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000682
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