β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells

Malignant glioblastoma multiforme is one of the most aggressive human cancers, with very low survival rates. Recent studies have reported that glioma stem-like cells transdifferentiate into endothelial cells, indicating a new mechanism for tumor angiogenesis and potentially providing new therapeutic...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Cui, Chunhong, Chen, Xiaoning, Liu, Ying, Cao, Benjin, Xing, Yang, Liu, Chanjuan, Yang, Fan, Li, Yinan, Yang, Tianxiao, Hua, Lingyang, Tian, Mi, Wei, Yuanyan, Gong, Ye, Jiang, Jianhai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808780/
https://ncbi.nlm.nih.gov/pubmed/29269413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000682
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