β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells

Malignant glioblastoma multiforme is one of the most aggressive human cancers, with very low survival rates. Recent studies have reported that glioma stem-like cells transdifferentiate into endothelial cells, indicating a new mechanism for tumor angiogenesis and potentially providing new therapeutic...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Cui, Chunhong, Chen, Xiaoning, Liu, Ying, Cao, Benjin, Xing, Yang, Liu, Chanjuan, Yang, Fan, Li, Yinan, Yang, Tianxiao, Hua, Lingyang, Tian, Mi, Wei, Yuanyan, Gong, Ye, Jiang, Jianhai
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808780/
https://ncbi.nlm.nih.gov/pubmed/29269413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000682
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