Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory...

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Bibliographische Detailangaben
Hauptverfasser: Wei, Yuanyan, Jiang, Yizhou, Zou, Fei, Liu, Yingchao, Wang, Shanshan, Xu, Nuo, Xu, Wenlong, Cui, Chunhong, Xing, Yang, Liu, Ying, Cao, Benjin, Liu, Chanjuan, Wu, Guoqiang, Ao, Hong, Zhang, Xiaobiao, Jiang, Jianhai
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637720/
https://ncbi.nlm.nih.gov/pubmed/23569237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217002110
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