Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression

The single nucleotide polymorphism located within the IFNL3 (also known as IL28B) promoter is one of the host factors associated with hepatitis C virus (HCV) clearance by interferon (IFN)-α therapy; however the mechanism remains unknown. We investigated how IL28B gene polymorphism influences HCV cle...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Ferraris, Pauline, Chandra, Partha K., Panigrahi, Rajesh, Aboulnasr, Fatma, Chava, Srinivas, Kurt, Ramazan, Pawlotsky, Jean-Michel, Wilkens, Ludwig, Osterlund, Pamela, Hartmann, Rune, Balart, Luis A., Wu, Tong, Dash, Srikanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807932/
https://ncbi.nlm.nih.gov/pubmed/26896692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.11.027
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