IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System

BACKGROUND: HCV replication in persistently infected cell culture remains resistant to IFN-α/RBV combination treatment, whereas IFN-λ1 induces viral clearance. The antiviral mechanisms by which IFN-λ1 induces sustained HCV clearance have not been determined. AIM: To investigate the mechanisms by whi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Aboulnasr, Fatma, Hazari, Sidhartha, Nayak, Satyam, Chandra, Partha K., Panigrahi, Rajesh, Ferraris, Pauline, Chava, Srinivas, Kurt, Ramazan, Song, Kyongsub, Dash, Asha, Balart, Luis A., Garry, Robert F., Wu, Tong, Dash, Srikanta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686105/
https://ncbi.nlm.nih.gov/pubmed/26657215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141655
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