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Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains
[Image: see text] A structure–activity relationship study of potent TIQ15-derived CXCR4 antagonists is reported. In this investigation, the TIQ15 side-chain was constrained to improve its drug properties. The cyclohexylamino congener 15a was found to be a potent CXCR4 inhibitor (IC(50) = 33 nM in CX...
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| Wydane w: | ACS Med Chem Lett |
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| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2017
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807867/ https://ncbi.nlm.nih.gov/pubmed/29456793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00406 |
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