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Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion

Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross-protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, altho...

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Bibliographic Details
Published in:mSphere
Main Authors: Lindesmith, Lisa C., Mallory, Michael L., Debbink, Kari, Donaldson, Eric F., Brewer-Jensen, Paul D., Swann, Excel W., Sheahan, Timothy P., Graham, Rachel L., Beltramello, Martina, Corti, Davide, Lanzavecchia, Antonio, Baric, Ralph S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806210/
https://ncbi.nlm.nih.gov/pubmed/29435493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00518-17
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