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Genetic Mapping of a Highly Variable Norovirus GII.4 Blockade Epitope: Potential Role in Escape from Human Herd Immunity

Noroviruses account for 96% of viral gastroenteritis cases worldwide, with GII.4 strains responsible >80% of norovirus outbreaks. Histo-blood group antigens (HBGAs) are norovirus binding ligands, and antigenic and preferential HBGA binding profiles vary over time as new GII.4 strains emerge. The...

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Detalhes bibliográficos
Main Authors: Debbink, Kari, Donaldson, Eric F., Lindesmith, Lisa C., Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255819/
https://ncbi.nlm.nih.gov/pubmed/22090110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06189-11
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