Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

BACKGROUND: During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen receptors (CARs) and bispecific BiTE(®) antibody constructs. In this context, HCM...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Proff, Julia, Brey, Charlotte U., Ensser, Armin, Holter, Wolfgang, Lehner, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804023/
https://ncbi.nlm.nih.gov/pubmed/29422056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1394-x
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