Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy

The success of adoptive therapy using chimeric antigen receptor (CAR)–expressing T cells partly depends on optimal CAR design. CARs frequently incorporate a spacer/linker region based on the constant region of either IgG1 or IgG4 to connect extracellular ligand-binding with intracellular signaling d...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Jonnalagadda, Mahesh, Mardiros, Armen, Urak, Ryan, Wang, Xiuli, Hoffman, Lauren J, Bernanke, Alyssa, Chang, Wen-Chung, Bretzlaff, William, Starr, Renate, Priceman, Saul, Ostberg, Julie R, Forman, Stephen J, Brown, Christine E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395772/
https://ncbi.nlm.nih.gov/pubmed/25366031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.208
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