Chimeric antigen receptors (CARs) incorporating mutations in the IgG4 Fc spacer region to eliminate Fc receptor recognition results in improved CAR T cell persistence and anti-tumor efficacy

Gelijkaardige items

• Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy
  door: Jonnalagadda, Mahesh, et al.
  Gepubliceerd in: (2015)
• T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
  door: Mardiros, Armen, et al.
  Gepubliceerd in: (2013)
• T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia
  door: Mardiros, Armen, et al.
  Gepubliceerd in: (2015)
• Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains
  door: Proff, Julia, et al.
  Gepubliceerd in: (2018)
• Acute myeloid leukemia therapeutics: CARs in the driver’s seat
  door: Mardiros, Armen, et al.
  Gepubliceerd in: (2013)