Cytomegalovirus-Infected Cells Resist T Cell Mediated Killing in an HLA-Recognition Independent Manner

In order to explore the potential of HLA-independent T cell therapy for human cytomegalovirus (HCMV) infections, we developed a chimeric antigen receptor (CAR) directed against the HCMV encoded glycoprotein B (gB), which is expressed at high levels on the surface of infected cells. T cells engineere...

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Foilsithe in:Front Microbiol
Main Authors: Proff, Julia, Walterskirchen, Christian, Brey, Charlotte, Geyeregger, Rene, Full, Florian, Ensser, Armin, Lehner, Manfred, Holter, Wolfgang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2016
Ábhair:
Microbiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899442/
https://ncbi.nlm.nih.gov/pubmed/27375569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00844
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