Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as possible target antigens. Detailed analysis of the expression of MICA, MICB, ULBP-1, -2, and -3 in fourteen ESFT cell lines revealed consi...

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Detalhes bibliográficos
Main Authors: Lehner, Manfred, Götz, Gabriel, Proff, Julia, Schaft, Niels, Dörrie, Jan, Full, Florian, Ensser, Armin, Muller, Yves A., Cerwenka, Adelheid, Abken, Hinrich, Parolini, Ornella, Ambros, Peter F., Kovar, Heinrich, Holter, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280271/
https://ncbi.nlm.nih.gov/pubmed/22355347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031210
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