SLFN11 blocks stressed replication forks independently of ATR

SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...

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Publicat a:Mol Cell
Autors principals: Murai, Junko, Tang, Sai-Wen, Leo, Elisabetta, Baechler, Simone A, Redon, Christophe E., Zhang, Hongliang, Al Abo, Muthana, Rajapakse, Vinodh N, Nakamura, Eijiro, Miller Jenkins, Lisa M., Aladjem, Mirit I, Pommier, Yves
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802881/
https://ncbi.nlm.nih.gov/pubmed/29395061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.012
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