Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor against replication stress. Here, we show that SLFN11 increases chromatin accessibility genome wide, prominently at active promoters in response to replication stress induced by the checkpoint kinase 1 (CHK1) inhibitor pre...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Murai, Junko, Zhang, Hongliang, Pongor, Lorinc, Tang, Sai-Wen, Jo, Ukhyun, Moribe, Fumiya, Ma, Yixiao, Tomita, Masaru, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7240837/
https://ncbi.nlm.nih.gov/pubmed/32209474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.117
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