Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

Poly(ADP-ribose) polymerase inhibitors (PARPIs) kill cancer cells by trapping PARP1 and PARP2. Talazoparib, the most potent PARPI inhibitor (PARPI), exhibits remarkable selectivity among the NCI-60 cancer cell lines beyond BRCA inactivation. Our genomic analyses reveal high correlation between respo...

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發表在:Oncotarget
Main Authors: Murai, Junko, Feng, Ying, Yu, Guoying K., Ru, Yuanbin, Tang, Sai-Wen, Shen, Yuqiao, Pommier, Yves
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340226/
https://ncbi.nlm.nih.gov/pubmed/27708213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12266
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