SLFN11 blocks stressed replication forks independently of ATR

SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Murai, Junko, Tang, Sai-Wen, Leo, Elisabetta, Baechler, Simone A, Redon, Christophe E., Zhang, Hongliang, Al Abo, Muthana, Rajapakse, Vinodh N, Nakamura, Eijiro, Miller Jenkins, Lisa M., Aladjem, Mirit I, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802881/
https://ncbi.nlm.nih.gov/pubmed/29395061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.012
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