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Eomesodermin increases survival and IL-2 responsiveness of tumor-specific CD8(+) T cells in an adoptive transfer model of cancer immunotherapy

Tumor-specific CD8(+) T cells often fail to elicit effective antitumor immune responses due to an inability to expand into a substantial effector population and persist long-term in vivo. Using an adoptive transfer model of cancer immunotherapy, we demonstrate that constitutive Eomes expression in t...

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Bibliographic Details
Published in:J Immunother
Main Authors: Furusawa, Aki, Reiser, John, Sadashivaiah, Kavitha, Simpson, Haley, Banerjee, Arnob
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801069/
https://ncbi.nlm.nih.gov/pubmed/29271784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000206
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