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New Insights into Structure–Activity Relationship of Ipomoeassin F from Its Bioisosteric 5-Oxa/Aza Analogues
Ipomoeassin F, a plant-derived macrolide, exhibited single-digit nanomolar growth inhibition activity against many cancer cell lines. In this report, a series of 5-oxa/aza analogues was prepared and screened for cytotoxicity. Replacement of 5-CH(2) with O/NH simplified the synthesis and led to only...
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| Publicado en: | Eur J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800971/ https://ncbi.nlm.nih.gov/pubmed/29291442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.11.022 |
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