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Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F

An efficient synthetic route for ipomoeassin F and its tiglate-modified analogues was developed. The route features late-stage conformation-controlled highly regioselective esterification of the glucose diol in the disaccharide core. The results from the NCI-60 cell line screens of ipomoeassin F wer...

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Pubblicato in:J Org Chem
Autori principali: Zong, Guanghui, Whisenhunt, Lucas, Hu, Zhijian, Shi, Wei Q.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483335/
https://ncbi.nlm.nih.gov/pubmed/28394135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b00409
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