Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

[Image: see text] Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC(50): from 1.8 nM) and in vitro protein translocation inhibition (IC(50): 35 nM) derived from ring expansion imply that the binding pocket of Sec61α (isoform 1) c...

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Publicat a:J Org Chem
Autors principals: Zong, Guanghui, Hu, Zhijian, Duah, Kwabena Baffour, Andrews, Lauren E., Zhou, Jianhong, O’Keefe, Sarah, Whisenhunt, Lucas, Shim, Joong Sup, Du, Yuchun, High, Stephen, Shi, Wei Q.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808706/
https://ncbi.nlm.nih.gov/pubmed/33264019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c01659
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