Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

[Image: see text] Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC(50): from 1.8 nM) and in vitro protein translocation inhibition (IC(50): 35 nM) derived from ring expansion imply that the binding pocket of Sec61α (isoform 1) c...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Org Chem
Auteurs principaux: Zong, Guanghui, Hu, Zhijian, Duah, Kwabena Baffour, Andrews, Lauren E., Zhou, Jianhong, O’Keefe, Sarah, Whisenhunt, Lucas, Shim, Joong Sup, Du, Yuchun, High, Stephen, Shi, Wei Q.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808706/
https://ncbi.nlm.nih.gov/pubmed/33264019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c01659
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires