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Design, Synthesis and Biological Evaluation of Fucose-Truncated Monosaccharide Analogues of Ipomoeassin F

Ipomoeassin F is a plant-derived macrocyclic glycolipid with single-digit nanomolar IC(50) values against cancer cell growth. In previous structure–activity relationship studies, we have demonstrated that certain modifications around the fucoside moiety did not cause significant cytotoxicity loss. T...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Zong, Guanghui, Hirsch, Melissa, Mondrik, Collin, Hu, Zhijian, Shi, Wei Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502735/
https://ncbi.nlm.nih.gov/pubmed/28465102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.04.065
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