Promotion of RAD51-mediated homologous DNA pairing by BRCA1-BARD1

The tumor suppressor complex BRCA1-BARD1 functions in DNA double-strand break repair by homologous recombination. Therein, BRCA1-BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for the recruitment of another tumor suppressor complex BRCA2-PALB2 and the...

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Udgivet i:Nature
Main Authors: Zhao, Weixing, Steinfeld, Justin B., Liang, Fengshan, Chen, Xiaoyong, Maranon, David G., Ma, Chu Jian, Kwon, Youngho, Rao, Timsi, Wang, Weibin, Chen, Sheng, Song, Xuemei, Deng, Yanhong, Jimenez-Sainz, Judit, Lu, Lucy, Jensen, Ryan B., Xiong, Yong, Kupfer, Gary M., Wiese, Claudia, Greene, Eric C., Sung, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800781/
https://ncbi.nlm.nih.gov/pubmed/28976962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24060
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