RAD51AP1 mediates RAD51 activity through nucleosome interaction

RAD51-associated protein 1 (RAD51AP1) is a key protein in the homologous recombination (HR) DNA repair pathway. Loss of RAD51AP1 leads to defective HR, genome instability, and telomere erosion. RAD51AP1 physically interacts with the RAD51 recombinase and promotes RAD51-mediated capture of donor DNA,...

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Publicado en:J Biol Chem
Autores principales: Pires, Elena, Sharma, Neelam, Selemenakis, Platon, Wu, Bo, Huang, Yuxin, Alimbetov, Dauren S., Zhao, Weixing, Wiese, Claudia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233230/
https://ncbi.nlm.nih.gov/pubmed/34058198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100844
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