RAD51AP1 mediates RAD51 activity through nucleosome interaction

RAD51-associated protein 1 (RAD51AP1) is a key protein in the homologous recombination (HR) DNA repair pathway. Loss of RAD51AP1 leads to defective HR, genome instability, and telomere erosion. RAD51AP1 physically interacts with the RAD51 recombinase and promotes RAD51-mediated capture of donor DNA,...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Pires, Elena, Sharma, Neelam, Selemenakis, Platon, Wu, Bo, Huang, Yuxin, Alimbetov, Dauren S., Zhao, Weixing, Wiese, Claudia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233230/
https://ncbi.nlm.nih.gov/pubmed/34058198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100844
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