Promotion of RAD51-mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex

The UAF1-USP1 complex deubiquitinates FANCD2 during execution of the Fanconi anemia DNA damage response pathway. As such, UAF1 depletion results in persistent FANCD2 ubiquitination and DNA damage hypersensitivity. UAF1 deficient cells are also impaired for DNA repair by homologous recombination. Her...

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Pubblicato in:Cell Rep
Autori principali: Liang, Fengshan, Longerich, Simonne, Miller, Adam S., Tang, Caroline, Buzovetsky, Olga, Xiong, Yong, Maranon, David G., Wiese, Claudia, Kupfer, Gary M., Sung, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381662/
https://ncbi.nlm.nih.gov/pubmed/27239033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.007
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