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Promotion of RAD51-mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex
The UAF1-USP1 complex deubiquitinates FANCD2 during execution of the Fanconi anemia DNA damage response pathway. As such, UAF1 depletion results in persistent FANCD2 ubiquitination and DNA damage hypersensitivity. UAF1 deficient cells are also impaired for DNA repair by homologous recombination. Her...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381662/ https://ncbi.nlm.nih.gov/pubmed/27239033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.007 |
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