Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease

Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Chen, Xiaoying, Farrokhi, Vahid, Singh, Pratap, Ocana, Mireia Fernandez, Patel, Jenil, Lin, Lih-Ling, Neubert, Hendrik, Brodfuehrer, Joanne
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800393/
https://ncbi.nlm.nih.gov/pubmed/29190188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1398873
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