Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease

Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:MAbs
Egile Nagusiak: Chen, Xiaoying, Farrokhi, Vahid, Singh, Pratap, Ocana, Mireia Fernandez, Patel, Jenil, Lin, Lih-Ling, Neubert, Hendrik, Brodfuehrer, Joanne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2017
Gaiak:
Brief Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800393/
https://ncbi.nlm.nih.gov/pubmed/29190188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1398873
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