Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease

Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb...

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Bibliographic Details
Published in:MAbs
Main Authors: Chen, Xiaoying, Farrokhi, Vahid, Singh, Pratap, Ocana, Mireia Fernandez, Patel, Jenil, Lin, Lih-Ling, Neubert, Hendrik, Brodfuehrer, Joanne
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800393/
https://ncbi.nlm.nih.gov/pubmed/29190188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1398873
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