Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys

For therapeutic monoclonal antibodies (mAbs) against soluble ligands, the free ligand level can, theoretically, be used as a surrogate for efficacy. However, it can be extremely challenging technically to measure free ligand level in the presence of an excessive amount of antibody–ligand complex. Th...

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Detalhes bibliográficos
Main Authors: Wang, Weirong, Wang, Xiaofeng, Doddareddy, Rajitha, Fink, Damien, McIntosh, Thomas, Davis, Hugh M., Zhou, Honghui
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889526/
https://ncbi.nlm.nih.gov/pubmed/24287601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9545-8
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