Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice

PURPOSE: TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) currently under clinical development for schizophrenia. In this study, a mechanistic multilayer quantitative model that parsimoniously connects pharmacokinetics (PK), target occupancy (TO) and D-serine concent...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Yoneyama, Tomoki, Sato, Sho, Sykes, Andy, Fradley, Rosa, Stafford, Stuart, Bechar, Shyam, Howley, Eimear, Patel, Toshal, Tagawa, Yoshihiko, Moriwaki, Toshiya, Asahi, Satoru
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478952/
https://ncbi.nlm.nih.gov/pubmed/32901384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02893-x
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