Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

OBJECTIVES: To evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-438 (vonoprazan, a potassium-competitive acid blocker) in healthy male subjects. METHODS: In two phase I, randomized, double-blind, placebo-controlled, single rising-dose studies, healthy male subjects (Japan...

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Detalhes bibliográficos
Publicado no:Clin Transl Gastroenterol
Principais autores: Sakurai, Yuuichi, Nishimura, Akira, Kennedy, Gale, Hibberd, Mark, Jenkins, Richard, Okamoto, Hiroyuki, Yoneyama, Tomoki, Jenkins, Helen, Ashida, Kiyoshi, Irie, Shin, Täubel, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Contributions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816246/
https://ncbi.nlm.nih.gov/pubmed/26111126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2015.18
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