Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects

BACKGROUND: TAK-438 (vonoprazan) is a potassium-competitive acid blocker that reversibly inhibits gastric H(+), K(+)-ATPase. AIM: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-438 in healthy Japanese and non-Japanese men. METHODS: In two Phase I, randomised, doub...

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Detalhes bibliográficos
Publicado no:Aliment Pharmacol Ther
Main Authors: Jenkins, H, Sakurai, Y, Nishimura, A, Okamoto, H, Hibberd, M, Jenkins, R, Yoneyama, T, Ashida, K, Ogama, Y, Warrington, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2015
Assuntos:
Randomised Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654261/
https://ncbi.nlm.nih.gov/pubmed/25707624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.13121
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