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The binding selectivity of vonoprazan (TAK-438) to the gastric H(+),K(+)−ATPase
BACKGROUND: The gastric H(+),K(+)-ATPase is the preferred target for acid suppression. Until recently, the only drugs that effectively inhibited this ATPase were the proton pump inhibitors (PPIs). PPIs are acid-activated prodrugs that require acid protection. Once acid activated, PPIs bind to cystei...
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| Vydáno v: | Aliment Pharmacol Ther |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626316/ https://ncbi.nlm.nih.gov/pubmed/26423447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.13414 |
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