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A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy
Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic–pharmacodynamic (PK/PD) model that used drug–target binding kinetics to successfully predict the in vivo...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417014/ https://ncbi.nlm.nih.gov/pubmed/28507715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03306g |
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