A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic–pharmacodynamic (PK/PD) model that used drug–target binding kinetics to successfully predict the in vivo...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Daryaee, Fereidoon, Zhang, Zhuo, Gogarty, Kayla R., Li, Yong, Merino, Jonathan, Fisher, Stewart L., Tonge, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2017
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417014/
https://ncbi.nlm.nih.gov/pubmed/28507715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03306g
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