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Pharmacokinetic-Pharmacodynamic Models that Incorporate Drug-Target Binding Kinetics
Pharmacokinetic/pharmacodynamic (PK/PD) models predict the effect time course resulting from a drug dose. In this review we summarize the development of mechanistic PK/PD models that explicitly integrate the kinetics of drug-target interactions into predictions of drug activity. Such mechanistic mod...
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| 發表在: | Curr Opin Chem Biol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7050630/ https://ncbi.nlm.nih.gov/pubmed/31030171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.03.008 |
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