Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have observed that PK of IgG molecules vary widely, even when they share identical Fc domains. This led us to hypothesize that do...

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Publicado no:MAbs
Main Authors: Piche-Nicholas, Nicole M., Avery, Lindsay B., King, Amy C., Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M., Tchistiakova, Lioudmila, Katragadda, Madan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800364/
https://ncbi.nlm.nih.gov/pubmed/28991504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1389355
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