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Polycomb Repressive Complex 2 methylates Elongin A to regulate transcription
Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of neoplastic malignancies, which is believed to involve methylation of H3K27. However, the full spectrum of...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800316/ https://ncbi.nlm.nih.gov/pubmed/29153392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.025 |
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