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Polycomb Repressive Complex 2 methylates Elongin A to regulate transcription

Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of neoplastic malignancies, which is believed to involve methylation of H3K27. However, the full spectrum of...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Ardehali, M. Behfar, Anselmo, Anthony, Cochrane, Jesse C., Kundu, Sharmistha, Sadreyev, Ruslan I., Kingston, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800316/
https://ncbi.nlm.nih.gov/pubmed/29153392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.025
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