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Cellular FLIP long isoform (cFLIP(L))–IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression
Interferon α (IFNα) is important for antiviral and anticancer defenses. However, overproduction is associated with autoimmune disorders. Thus, the cell must precisely up- and down-regulate IFNα to achieve immune system homeostasis. The cellular FLICE-like inhibitory protein (cFLIP) is reported to in...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5798304/ https://ncbi.nlm.nih.gov/pubmed/29222334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000541 |
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