Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

To provide protective immunity against circulating primary HIV-1 strains, a vaccine most likely has to induce broadly neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) spike. Recombinant Env trimers such as the prototype BG505 SOSIP.664 that closely mimic the native Env spike can indu...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: de Taeye, Steven W., de la Peña, Alba Torrents, Vecchione, Andrea, Scutigliani, Enzo, Sliepen, Kwinten, Burger, Judith A., van der Woude, Patricia, Schorcht, Anna, Schermer, Edith E., van Gils, Marit J., LaBranche, Celia C., Montefiori, David C., Wilson, Ian A., Moore, John P., Ward, Andrew B., Sanders, Rogier W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2018
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798299/
https://ncbi.nlm.nih.gov/pubmed/29222332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000709
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